Dr. Li Dak Sum & Yip Yip Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, Zhejiang, China

Director: Hong-Wei Ouyang, M.D.

The Center for Stem Cells and Tissue Engineering was established in 2005 when Professor Hong-Wei Ouyang joined Zhejiang University, School of Medicine. Professor Ouyang’s group focuses on the research of tissue engineering and regenerative therapy of the musculoskeletal system, especially on tendon and joint cartilage tissues, from basic research to clinical translational medicine.

Our tendon and cartilage research has identified the biomarkers of tendon stem cells and developed silk based scaffolds for tissue engineered tendon. Meanwhile, we have established a serum-free culture method for cartilage stem cells as well as chondrocytes and fabricated cartilage tissue engineering scaffold. In the future, we will not only continue optimizing tendon/cartilage cells manipulation and tissue specific scaffold design, but also illustrating the tissue development program and pathogenesis of tendon and joint cartilage.

In translational medicine, Professor Ouyang is the pioneer of clinical translation in China orthopedic regenerative medicine and has established a standard approach for tissue engineered cartilage (TEC) transplantation. He was authorized by SFDA and MOH in China to formulate the guidance for assessment of implants for cartilage repair and therapeutic transplantation of engineered tissues, respectively. Professor Ouyang is now the president elect for the China Society of Tissue Engineering and Regenerative Medicine (Term-China) and the leader of the China Orthopaedic Regenerative Medicine Group (CORMed)

During the last decade, we have filed more than twenty national patent applications (eleven approved) and published more than seventy original research papers in leading regenerative medicine journals. These achievements have also been recognized by the Ministry of Education with the Science & Technology Progress 1st Award (2012) and 2nd Award (2014), as well as by the international academic societies, the Young Investigator Award (2012) from the International Symposium on Ligaments & Tendons (ISL&T) and the best research paper (2013) from the International Cartilage Research Society (ICRS2013).